Isosorbide Dinitrate Injection
Isosorbide dinitrate is an organic nitrate vasodilator. When administered intravenously, it rapidly dilates venous vascular beds and coronary arteries, reducing preload and afterload, which decreases myocardial oxygen demand and improves cardiac output.
Dosage by Body Weight
For intravenous infusion only. The dosage should be adjusted according to the individual patient response. The typical starting dose in adults is 2 mg/hour to 10 mg/hour, which can be titrated up to 20 mg/hour depending on clinical response and blood pressure.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Pediatric safety and efficacy have not been established. Requires expert pediatric cardiology supervision and precise infusion pumps.
- Body Weight
- 5-7 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Requires intensive hemodynamic monitoring in a pediatric ICU setting.
- Body Weight
- 8-10 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Infusion rate must be carefully calculated on a microgram/kg/minute basis if indicated.
- Body Weight
- 11-15 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Continuous monitoring of blood pressure and heart rate is mandatory.
- Body Weight
- 16-20 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Requires intensive care monitoring and precise dilution protocols.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Pediatric safety and efficacy have not been established. Requires expert pediatric cardiology supervision and precise infusion pumps. |
| 5-7 kg | Not routine | Use only if prescribed | Requires intensive hemodynamic monitoring in a pediatric ICU setting. |
| 8-10 kg | Not routine | Use only if prescribed | Infusion rate must be carefully calculated on a microgram/kg/minute basis if indicated. |
| 11-15 kg | Not routine | Use only if prescribed | Continuous monitoring of blood pressure and heart rate is mandatory. |
| 16-20 kg | Not routine | Use only if prescribed | Requires intensive care monitoring and precise dilution protocols. |
Formulation
Purpose
Used for the treatment of unresponsive left ventricular failure secondary to acute myocardial infarction, control of refractory angina pectoris, and to facilitate coronary angioplasty.
Generic Name
Isosorbide DinitrateBranded Drug Names
Isosorbide Dinitrate Injection is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.